Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). Or is it worth having the actual tests done? If it were me and it was my last embryo I would definitely ask about (possibly even push for) immune protocol and the ERA just to cover all my bases. I'm so sorry for your loss. With the second, the only change was to add low dose steroids. My doctor is recommending a Receptiva test to uncover any other reasons why the pregnancies won't last. I did switch clinics in the middle and felt that my new clinic cared more about me and was more aggressive in testing for other things and adding new medications to my cycles. Hi Mogwai_2 Theses are rates for PGS normal embryos. Good luck to you on this journey and I hope round 2 is successful for you!! Check out mycomplete guide to embryo grading and success ratesto learn more about embryo development, grading and success rates. It had an extra chromosome from the sperm and another from the egg. I guess this probably qualifies me as a poor responder which obviously doesn't feel good after all the other issues we've had. I know Im my heart I want to try again, but my brain is working overtime too - odds, finances, and the risk of suffering all over again, Im so sorry to hear all this! About 7 months later I transferred a day 7. All genetically untested embryos. I go for my next Beta tomorrow. Hoping to hear from them soon . I know how hard this all is. This means that these women had euploid embryos for transfer. We have one (and only one) 4bb PGS normal embryo. This was our first trial. Once they see it on an U/S, I think it becomes a clinical pregnancy. Some of the issues with the studies included in the meta-analysis were brought up: Future studies should focus on single embryo transfers, and in women >35, to see if PGT-A truly has a reduction in miscarriage rates for this age group. A doctor can confirm it by testing blood for human chorionic gonadotropin (hCG . We found out yesterday we were having a chemical pregnancy, my second beta didnt double. No PGS testing I know PGS tested embryos can still have issues but its been 4 transfers now with no success so Im wondering if theres a deeper issue. This is my second failure of a PGS tested embryo, and the first on this immune suppressing protocol. If you haven't had multiple losses/failed attempts feel free to comment but please be empathetic when doing so. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. We are so happy about that, we just want this one to be the one. However, almost all studies and clinic data show that IVF success rates indicates higher pregnancy rates. Congratulations again on your success!!! Or is that the reason they don't continue to progress? So mosaics can have a varying rates of miscarriage depending on the type of abnormality present. My RE didnt change a thing between round 1 and round 2, and I didnt do anything differently. We were told not to worry and try again after a month, and in March I found I was pregnant again but this turned out to be a chemical pregnancy. I am 41 years old. Chemical pregnancy is an early miscarriage. First, PGS improves pregnancy rates. That embryo implanted but resulted in a chemical pregnancy. Terms are highlighted every 3rd time to avoid repetition. A 2019 multicenter and international RCT (the STAR trial) compared euploid and untested embryo transfers. The only thing different medication wise was that I took a baby aspirin once daily starting the day of transfer the second time. PGS testing done this round 8 high quality normal embryos. This isnt very surprising considering these embryos have no cells that are euploid in order to self-correct (read more about that here). (2017)found that Day 5 euploids had a higherongoing pregnancyrate vs Day 6 euploids (51.9% vs 32.7%). I know in our case our embryos had epigenetic issues which meant that our baby that we miscarried probably had structural issues. Check here for the full glossary (please excuse the repeated terms!). I actually didnt do acupuncture the second cycle, but I was in great shape. , ERA was a game changer for me! My result came with a high risk, 1 in 11 chances of the baby having Down Syndrome. Did anyone else have success after failure with PGS? For more up-to-date information on this topic check out my other posts that are tagged withEmbryo rebiopsy. Ive done intralipid infusions and Neupogen each time in the case I had an autoimmune disorder or natural killer cells so I dont think that would be the issue. You have to do whatever you feel comfortable with and its so unfortunate that money plays a huge role in these decisions. However, the two transfers we did werent PGS tested. , thats definitely worth looking into as well! 2 - IVF BFN I am 42. Then a frozen cycle BFN. This may be used to avoid a gender-linked genetic disorder or (more rarely) for family balancing. It's an autoimmune blood clotting disorder that can cause recurrent miscarriage. My first, was a success. With a PGS tested embryo this time. I'm glad we did - because my ERA results were abnormal and I needed 12 more hours of PIO. Have they tried changing your protocol (ie from natural to artificial cycle)? Group Black's collective includes Essence, The Shade Room and Naturally Curly. Hello- PGS enhances the success of IVF but not in all cases; the success rates vary by age. Chances for getting a euploid embryo A recent 2019 study looked at 130,000 biopsies by NGS tested (this is the current testing method): Donor eggs: 63.1% euploid <35 years: 59.5% euploid 35-37 years: 50.3% euploid 38-40 years: 38.3% euploid 41-42 years: 26.8% euploid 43-44 years: 24% euploid But what about the women who didnt get blasts? A genetically normal embryo has a 70% chance of a positive pregnancy test in any woman, whether she is 20 years old or 40 years old. That makes me feel better about transferring to another clinic, which Im thinking might be the best bet at this point! My TSH was marginally high and I started synthroid. We decided to see an RE given our age. We had 30 eggs retrieval. Consult with your doctor before making any treatment changes. Mosaics are embryos that have a mix of euploid and aneuploid cells. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Trade-offs of PGT-A (or PGS) Poor quality embryos are they worth PGS testing? Best of luck to you with your upcoming FET, my thoughts and prayers are with you! This was something that almost all of our embryos had problems with (a high drop off rate of embryos growing in the lab and all were always low rated if they made it to blastocyst stage). The psychologist who ran the group, who also happened to be an RE at my fertility clinic, explained that sometimes you have a seemingly perfect embryo, perfect uterine lining, and the FET just fails. Hello, I hope the ERA works too. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Well start with euploids, then mosaics, and end with fully aneuploid embryos. According to the authors, the >35 group analysis should be interpreted with caution as the sample size was small. MENTS my 3rd FET was a success end MENTS. I asked her can we do bloodwork to see what couldve caused the miscarriage (I.e immune complex, blood clotting disorder or inflammation) and she doesnt think I need to and how we should proceed with the same protocol again and I dont know how to feel about this unable to sleep. Weve discussed euploid embryos, mosaic embryos, so what about aneuploid embryos? I am currently 6w5d pregnant, which is the farthest Ive been. After 10 days, they came back and said that it was low and that i should mentally prepare myself for a chemical pregnancy. You can check out my summary of the study here. Its very disheartening though. Obviously, when we look at transfer rates with PGS tested embryos, we are not including all the women who didnt have anything to transfer. They biopsied those 2 embryos and send off the cells for PGS testing. I an 33 and my husband is 37. Maybe the wash too? That is, you definitely need an embryo with normal chromosome, but it's not the only variable to consider. In my case, my miscarriage was potentially caused by a partial uterine septate that my doctor identified via sonohystergram and removed via hysteroscopy. Hi everyone. Normally, we have 23 pairs of chromosomes (or 46 in total) one pair comes from the egg from our biological mother, and the other comes from the sperm from our biological father. Check here for the full glossary (please excuse the repeated terms!). Please specify a reason for deleting this reply from the community. Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). , dont be sorry! Thank you TXtoCA, Im definitely planning to make changes. So the advantage with PGT-A may be in determining which embryos are completely unfit for transfer, at least based on this study. But if you dont like the extra meds you could talk with your current or new clinic about not doing it and get their thoughts on it. sd84. ALL THREE DID!!! Or they did but they were all aneuploid? I might actually look into that. Thought this was tested out, but apparently that can't be detected by the PGT test. We PGS tested the whole batch of embryos at once at the end of all the retrievals. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. thank you for sharing your success story! This November I did a frozen transfer with an untested, five day embryo and Im 9 weeks now. While my clinic has had great success with PGS transfers they did say they expect implantation rates to end up averaging 90% for PGS normal embryos and I believe miscarriage rates are also lower. Ive had two biochemical losses with day 6 4BC euploids and with 1 day 6 4BC left to try, Im wondering our odds. I have expressed my concern but my RE believes it is more about the pattern. I think the ERA is a great idea too. I was told by my doctor that when it is a PGS embryo that is miscarried, it is a 50% chance it was something else with the embryo (structural issues with the organs or placenta) and a 50% chance it was something about the moms body. Is it because they were early blastocysts? See the chart below from the CDC (2016 data): In this post well look at the different miscarriage rates that all these types of PGT-A tested embryos have. I feel like your doctor should have mentioned the ERA and biopsy by now. my first 2 cycles were artificial but my last 2 were natural and unfortunately no luck :( Hopefully we can get somewhere with the ERA. Please whitelist our site to get all the best deals and offers from our partners. For women 35-40 years old, there was no statistical difference (8.2% for PGT-A vs 11.0% for untested). I will ask my dr about this. Capalbo et al. He earned his MSc in 2012 for his research on inflammation and lung cancerand started Remembryo in 2018 to help people understand the evidence behind common IVF topics. Check here for the full. I know she's going to ask me whether I want to proceed or not unless these 3 follicles really change overnight, of which I'm not getting my hopes up. History We strive to provide you with a high quality community experience. My husband and I started trying to get pregnant about a year ago (we're both 35). Was just curious if the percentages of a live birth increase after a positive pregnancy test. I just received news today that out of our 14 blastocysts only 4 passed pgs and 1 with no result that we are retesting. Did you get your BFP on IVF post the antibiotics or naturally? I have considered going to Braverman in NYC but I think that Kofinas tested me for everything Braverman tests for. One clinic determined IVF with PGS success rates to have a 10% higher pregnancy rate. Im still taking it! We did do some things differently, however my RE did these things more to appease me because he knew how frustrated I was than because he thought they were medically necessary. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. Best of luck to you. No clinic ended up quoting more than 60-70% . However, these differences were not found in women older than 30 years. Please can you offer a perspective? . The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. How did your pregnancy turn out? We started some workup with my OB (TSH, karyotyping and carrier testing). Took 2 years of "fighting" but looking back all the money, pain. Did your doctor have your SO go through the rounds of antibiotics as well? 35 years old We were hoping for a Christmas miracle however that was short lived. Well also look at the chances of getting a euploid based on age, the impact of embryo grade and the day it was frozen (Day 5, 6 or 7), and how rebiopsies or thaw and biopsies fare for success rates. Thanks! I only have embryo left ugh . 2005-2023Everyday Health, Inc., a Ziff Davis company. At this point I am wondering the following: I felt like a number in his practice, and I think he was milking my insurance for all he could get. While those are great odds, sometimes the FET fails. If your protocol did not have one or the other perhaps you can ask your RE about it. (I was taking baby aspirin and Lovenox 2x/day for blood clotting disorders as well as Prednisone 30 mg /day and Intralipid transfusions weekly for elevated NK cells). We transferred our only day 6/PGS tested Euploid embryo on December 10,2020. Ill have to ask my RE for options. We did accupuncutre 2x a week prior to transfer and a pre/post on transfer day as well. So sorry this happened and good luck to you. may be contradicted by other studies. Do the birth success rates of pgs tested embryos include both those that get a positive pregnancy test and those that dont? Odds of success are roughly 70 percent. 5AB euploid embryo. Chemical pregnancies occur so early that many people who miscarry don't realize it. Miscarriage of PGT tested embryo. I was told by my doctor that when it is a PGS embryo that is miscarried, it is a 50% chance it was something else with the embryo (structural issues with the organs or placenta) and a 50% chance it was something about the moms body. 2014). When we started I was told by an RE I had a 2% chance of having a baby with my own eggs. The results come back as euploid (meaning theres 46 chromosomes), aneuploid (meaning theres a number of chromosomes besides 46) or mosaic (meaning theres a mix of euploid and aneuploid cells). The results came back just this week saying that I was "pre-receptive" and recommended one day more of progesterone before doing the transfer to get to a more "ideal" transfer state. I cried the whole way home. Every positive thing helps! Note that once you confirm, this action cannot be undone. Thanks for commenting! After my negative, we did ERA and had a hysteroscopy to correct a small septum. I just officially confirmed another Chemical pregnancy for me. It was a chemical pregnancy. Find advice, support and good company (and some stuff just for fun). My RE also encouraged us to just try another transfer rather than an ERA after our first chemical but then was on board after the second chemical happened. Another thing to consider: Has your doctor done a hysteroscopy? Now I wonder if that could have been the culprit. There was also no difference with Day 7, although the sample size was very small. Theper retrievalstatistic helps to see the chancesbefore PGStesting. Disclaimer: Any studies presented here may be contradicted by other studies. As for boosting chances with two put back it should not be the trick. Your experience is so inspiring, thank you for sharing . Neal et al. Hi! Sorry to hear about your recent cycle. Thanks so much in advance for any feedback. A chemical pregnancy is an early pregnancy loss before ultrasounds can detect a fetus. You got this! Terms are highlighted every 3rd time to avoid repetition. Endomitritis is basically an inflammation in the uterus that makes it inhospitable for an embryo to implant or grow. Do you think it's worth it as last time I had a medicated cycle and it was a . MENTS THROUGHOUT MENTS For example, say a 39-year old woman has 3 embryos after her IVF cycle. Hi, i didnt have chemicals, I had bfn for my first two transfers. Can I ask why they didn't test them on Day 5? Note that this post is current as of July 2022. Wishing you lots of luck. Im so sorry youre going through that. I honestly wish I had but thats all hindsight now knowing what I knew. And congrats on your little girl! Euploid embryos are believed to have higher success rates and a reduced chance of miscarriage. I also want to add low dose prednisone and lovenox - I have heard from so many of you that even IF no autoimmune issues are found that this combo helps. Out of the 6 that were pgs tested, 3 came back normal and 1 came back inconclusive. My first FET failed and it was devastating. I miscarried a genetically normal baby girl at 8.5 weeks and they tested me for autoimmune disorders so that could be something to check for as well. So in your case it might be different since yours are chemical pregnancies but still worth asking I think :) Also someone above mentioned the endometrial biopsy which would also probably be a good idea. They found that: If you want to read my summary of this paper, check here. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Its good you will request the endomitritis biopsy. I know this is an incredibly hard time and it's a tough decision- best of luck to you- don't give up hope. And demand that my lining be over 8 before I allow another transfer to occur? I know Im shocked this was never brought up by my doctor, after everything. I'm curious if this might have something to do with it. Objective: To determine whether undetected aneuploidy contributes to pregnancy loss after transfer of euploid embryos that have undergone array comparative genomic hybridization (aCGH). Besides that, there are no gaurantees of both sticking. He was surprised my doctor was doing a Receptiva test naturally, without medication, since the idea is to simulate the same environment of a transfer, and was also surprised that my doctor had done a 5-day-post-retrieval-transfer in the first place. MENTS I am also going through a chemical pregnancy this week, but with an untested embryo (so, that's very likely the reason for my loss). Thankful for these forums! The chart below, based on information published in Reproductive Biomedicine Online, in 2016, shows:. is there another clinic in your area you can switch to? Tiegs (2020) in their multicenter prospective study transferred 414 blastocysts that were only tested using PGT-A after the pregnancy outcome. We had two from #4 cycle- one normal boy embryo and another that they said they didn't have enough material to test. Just trying to figure out what else I can do as I only have one embryo left. We have one day 7/Euploid Blast 5BB remaining on ice. My questions is only 28% of our blastocysts passed pgs testing which is quite low from what is predicted for those under 35. You said that The per retrieval statistic helps to see the chances before PGS testing. But it almost seems like there should be another set of statistics for better putting success rates into perspective. Fast Facts About PGS Testing Risks. Whitney et al. 4 PGT-M and PGT-A vs. Prenatal Testing I will look into this and mention to my doctor :) Ive been taking 10mg of prednisone but Ive never taken Lovenex. Also - wanted to add that I think my husband and I both did antibiotics still with our new clinic. Did our first FET in October with a supposedly PGT normal embryo. My FET is at the beginning of June so hoping that with this adjustment, a better outcome will occurs. (2021) in their multicenter prospective trial transferred 484 euploid, 282 low mosaic (where 20-30% of the cells are aneuploid) and 131 moderate mosaic (30-50%) embryos. 2) I feel like I've turned over every stone in trying to figure out what is wrong; does anyone have insight into how one would determine whether the problem is with the egg or with my body? Women above 35 seem to benefit the most with PGS . The embryo biopsy can be utilized to perform preimplantation genetic screening or PGS. We had PGS/PGD testing and an ERA. We put both in and im currently 8weeks pregnant. For <37, this was about 5, for 37-40 about 4, and for >40 about 3 (so older women tend to produce fewerblasts). Why did I miscarry a normal embryo? Use of this site is subject to our terms of use and privacy policy. Saw a heartbeat at 6 and 8 weeks then nothing at week 10. How does anyone not go completely crazy through this whole process???? The antibiotics were pretty strong, but I think they upset my stomach more than they did my husband. Im currently 17 weeks from another FET. It was a chemical pregnancy. Chemical pregnancy with PGS tested embryo. Some of the reasons quoted weren't even about the patient: it could have been damaged during the biopsy or thaw process in the lab, the transfer process could have been off, there's a margin of error with the testing itself, pgs doesn't tell us everything about an embryo, etc. For these groups, about 50% of biopsies had noeuploidembryos. Unfortunately this isnt very clear at this point. I don't know how many more cycles I can do as my emotional reserve is running low. Though it's one of the most successful forms of assisted reproductive technology, the live birth rate from one IVF cycle is about 55.6% for people under 35, and 40.8% for folks between the ages of. To count these women in, we can look at the per retrievaldata: Now when we look at everyone the stats look much different! We have some sort of make factor at play but no other known fertility issues. It kind of makes me wonder what they get out of their alternative recommendations. It provides a greater scope of information to geneticists, it reveals mosaicism within the embryos, as well as minimising the risk of receiving false positive or negative results. For now its probably best to avoid having to thaw and biopsy if possible. Why do we have to wait until we have a second devastating failure? I haven't done the transfer yet due to various reasons, and even though nothing is guaranteed, I like going into it knowing that I have a better chance because it is a normal embryo. For the autoimmune stuff above I was tested by Alexander Kofinas. Thats definitely worth looking into, thanks for sharing your experience! These studies were particularly small so drawing conclusions isnt really possible yet. Hopefully an ERA can shed some light on it! In the past PGS was seen as the holy grail - if the chromosomes are normal we should have implantation and a normal pregnancy. I agree with the others that you should push for some sort of testing or SOMETHING to investigate before trying again (if you haven't already). END MENTS We really expected to find success with our first pgs transfer even though our company and RE only quoted 60% odds per embryo transferits a good but tough reminder that its not expected to always work. (2017)found no difference in survival rates of embryos that were thawed and biopsied, then refrozen. Additionally, my RE says sometimes they will recommend these medications even if you test negative but have recurrent pgs transfer failures with no other explanations (you might want to search autoimmune immune protocol on these boards). I wanted to reach out and see if you know a way to find a surrogate on your own, rather than going thru an agency. We have our lining check on Friday. Good luck. My lining a week before transfer was 6.8, but trilaminar lining was present. Some are faster, and some are slower. I had been on birth control since I was 18 and had no idea what to expect when I came off it. This can be done! Would love to hear if it was successful - fingers crossed . About 7 months later I transferred a day 7. I took the year off to just work on myself and be in a better mental state. Or a fully aneuploid embryo? thanks so much! Meaning that if you begin a cycle, retrieve eggs, produce embryos, then do PGS testing, and at least one embryo comes back normal, 60 - 70% of the time it will lead to a live birth. Your clinic may have a better idea of how things work in their hands. I needed additional days of progesterone and that was corrected for my 2nd FET. ERA testing. Multiple losses due to chromosomal abnormality, did you do ivf? I also did Neupogen but they still wanted to test for autoimmune disorders. There isnt much data on it, and 2 of the 3 studies found no difference, so it isnt exactly clear. I did PGS testing. Genetic testing was normal. In contrast to mosaic embryos that are a mix of euploid and aneuploid cells, aneuploid embryos are completely aneuploid and all the cells are abnormal. (2014)found no difference inongoing pregnancieswith Day 5 or 6 euploids (about 50%). Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. My first FET was a day 6 5AA euploid embryo. It is seriously invaluable to me. Which was Claritin, pepcid, and baby aspirin. Again, Im sorry if thats not helpful especially since your RE didnt think it was necessary for you but that was just my experience. We put back a normal PGS tested embryo. Your post will be hidden and deleted by moderators. Dogpark in reply to Mogwai_2 3 years ago. Im so confused as my RE says that morphology doesnt matter if theyre euploid. If youre confused about the terminology youll see coming up, check my post on understanding PGS testing results. And congratulations on your pregnancy!! By screening out abnormal embryos with PGS, physicians can transfer just one chromosomally normal embryo, increasing the chances for having a successful singleton pregnancy and healthy child.

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